Editorial: Is heterozygosity for a Wilson's disease gene defect an important underlying cause of infantile and childhood copper toxicosis syndromes?
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چکیده
منابع مشابه
XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.
X-linked inhibitor of apoptosis (XIAP), known primarily for its caspase inhibitory properties, has recently been shown to interact with and regulate the levels of COMMD1, a protein associated with a form of canine copper toxicosis. Here, we describe a role for XIAP in copper metabolism. We find that XIAP levels are greatly reduced by intracellular copper accumulation in Wilson's disease and oth...
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ژورنال
عنوان ژورنال: The Journal of Trace Elements in Experimental Medicine
سال: 2000
ISSN: 0896-548X,1520-670X
DOI: 10.1002/1520-670x(2000)13:3<249::aid-jtra1>3.0.co;2-l